With such a large part of the world of manga being fantasy-based, it’s nice to see a series that has unique, but real life elements. I.S. (also known as Aiesu) by Chiyo Rokuhana follows the lives of people who are Inter Sexual, a condition in which a human has “reproductive or sexual anatomy that doesn’t seem to fit the typical definitions of female or male”. This could mean that a baby is born with outer male genitalia but has female genitalia inside, or vice versa. To clarify, this is different from being transgendered or transsexual. Trans individuals generally feel like they are the wrong gender because of internal beliefs, and can be classified as male or female while intersexuals can’t unless they take hormone therapy or sex reassignment surgeries.